guides and protocols from and for the sdb-lab
University Hospital Zurich

university hospital zurich

Department of Infectious Diseases and Hospital Epidemiology

University of Zurich

university of zurich

Faculty of Medicine

ETH Zurich

eth zurich

Department of Health Sciences and Technology

Bern University Hospital

Bern university hospital

Department of General Internal Medicine

University of Bern

university of bern

Faculty of Medicine

The community of cells lining our airways plays a crucial role to protect the host against invading pathogens. Similarly, the microorganisms colonizing the airways called "commensals" greatly influence respiratory tract health. However, we still lack a thorough understanding of how these commensals interact with the airway tissue to generate a protective barrier against pathogens. We propose to bridge this knowledge gap by utilizing an immunocompetent-humanized 3D-organotypic airway-tissue model to determine the crosstalk between epithelial barrier and resident immune cells during commensal versus pathogen colonization. Specifically, we will verify the concept of human-derived airway commensals as inducers of protective immune memory of airway tissues and lay the foundation for future application of commensals as therapeutics.

Research Team: Srikanth Mairpady Shambat, Chun-Chi Chang and Silvio Daniel Brugger